Thursday, December 24, 2009
open access: Cancer risk in MLH1, MSH2 and MSH6 mutation carriers; different risk profiles may influence clinical management
Subjects carrying a mutation in one of the MMR genes have a higher risk for developing colorectal cancer, but also for endometrial carcinoma and malignancies of the stomach, small bowel, ovaries, upper uroepithelial tract, biliary tract, skin and brain.(pancreas)
Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008
More importantly, tumour type and stage of disease are essential for drawing conclusions from such findings.
Carey et al.
2008 244 advanced ovarian cancer EORTC QLQ-C30 Performance status and global QOL scores at baseline were prognostic factors for both progression-free survival and overall survival.
Gupta et al.
2008 90 ovarian cancer Ferrans and Powers QLI No statistically significant prognostic
association of patient satisfaction with QOL was observed with survival.