Sunday, January 17, 2010
epigentics: The study of heritable changes in gene function that occur without a change in the DNA sequence
"CONCLUSIONS: Other mechanisms of variability, including epigenetic control of gene expression and copy number variation, may play important roles. In addition, nongenetic influences such as concurrent medications, and physiological and environmental factors could also affect individual responses to taxane and platinum therapy."
August 2009: Safety of (Avastin) Bevacizumab in Advanced Ovarian and Müllerian Cancers: A Review: Bevacizumab and Ovarian Cancer
"To date, several investigators (Table 1) have explored bevacizumab as a single agent or in combination with metronomic chemotherapy in the management of advanced ovarian cancer. All studies to date with bevacizumab as a single agent or in combination with chemotherapy have shown promising responses. The concern is centered on whether the benefit of this therapeutic agent outweighs its potential toxicity."
Note: long article
Note: not yet recruiting for patients - An interesting study bringing together genetics and immune system. Location: New York, U.S.A.
Clinical Trials Search of: Open Studies ovarian cancer Adult- new studies received from 12/01/2009 to 01/17/2010
13 new studies shown (non specific)
"Dr. Dizon is a medical oncologist specializing in women's cancers. He takes care of both breast and gynecologic cancers and has interests in new treatments, survivorship, and sexuality, and is Director of Medical Oncology at the Program in Women's Oncology at Women and Infants hospital of Rhode Island. He is also an Assistant Professor of Obstetrics-Gynecology and Internal Medicine at Alpert Medical School of Brown University."
free full access: JAMA -- Funding of US Biomedical Research, 2003-2008, January 13, 2010, Dorsey et al. 303 (2): 137
Note: charts for quick overviews
"...Small RNA cDNA libraries were constructed from RNA sample pools....and epithelial ovarian cancer specimens of serous, clear cell and endometrioid histologies....This report expands the body of miRNAs known to be expressed in epithelial ovarian cancer and provides a useful resource for future studies of the role of miRNAs in the pathogenesis and early detection of ovarian cancer."
"...The team made the discovery partly by accident. They were studying short pieces of RNA called micro RNAs in human tissue samples. These tiny pieces of RNA, discovered only a few years ago, play a big role in regulating genes, and are now known to be altered in cancer..... In a large majority of the cases, just by measuring the amount of micro RNA in the blood, we could tell who had cancer and who didn’t,” Tewari says."
Eva Longoria, Meryl Streep, Mario Batali, Stephen Colbert, Malcolm Gladwell, Yo-Yo Ma, Mike Nichols, Kristi Yamaguchi, Elizabeth Alexander, Queen Noor and Louise Erdrich have all submitted DNA tests for a new PBS television series FACES OF AMERICA.
Faces of America with Henry Louis Gates, Jr. airs on Wednesdays, February 10 – March 3, 2010 from 8-9 p.m. ET on PBS.
abstract: An effect from anticipation also in hereditary nonpolyposis colorectal cancer families without identified mutations.(Lynch Syndrome)
Note: this would apply to the many with no known mutations in the many genetic syndromes (eg. BRCA, Peutz-Jeghers Syndrome...)
"This observation suggests that anticipation may apply also to families without identified mutations and serves as a reminder to initiate surveillance programmes at young age also in HNPCC families with undefined genetic causes."